MET (phospho Y1349) polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
The MET (phospho Y1349) polyclonal antibody (Cat # PAB0535) is used in Western blot to detect MET-Y1349 in mouse kidney tissue lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of polyclonal antibody to Phospho-MET Y1349 on formalin-fixed paraffin-embedded human liver.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of MET.
Immunogen
Synthetic phosphopeptide corresponding to amino acids 1345-1357 residues surrounding Y1349 of human MET.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The MET (phospho Y1349) polyclonal antibody (Cat # PAB0535) is used in Western blot to detect MET-Y1349 in mouse kidney tissue lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of polyclonal antibody to Phospho-MET Y1349 on formalin-fixed paraffin-embedded human liver. -
Gene Info — MET
Entrez GeneID
4233Protein Accession#
NP_000236;P08581Gene Name
MET
Gene Alias
AUTS9, HGFR, RCCP2, c-Met
Gene Description
met proto-oncogene (hepatocyte growth factor receptor)
Gene Ontology
HyperlinkGene Summary
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
HGF receptor|OTTHUMP00000069168|SF receptor|met proto-oncogene|met proto-oncogene tyrosine kinase|oncogene MET|scatter factor receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation.
Wong AS, Roskelley CD, Pelech S, Miller D, Leung PC, Auersperg N.
Experimental Cell Research 2004 Sep; 299(1):248.
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MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met.
Higuchi T, Orita T, Katsuya K, Yamasaki Y, Akiyama K, Li H, Yamamoto T, Saito Y, Nakamura M.
Molecular and Cellular Biology 2004 Sep; 24(17):7456.
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Activation of the hepatocyte growth factor (HGF)-Met system in papillary thyroid cancer: biological effects of HGF in thyroid cancer cells depend on Met expression levels.
Mineo R, Costantino A, Frasca F, Sciacca L, Russo S, Vigneri R, Belfiore A.
Endocrinology 2004 Jun; 145(9):4355.
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Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation.
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