FOS (phospho T232) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of FOS.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T232 of human FOS.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Dot Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Dot Blot (Peptide)
Dot blot analysis of FOS (phospho T232) polyclonal antibody (Cat # PAB0475) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. P-Pab : phospho-antibody; P-Peptide : phospho-peptide; NP-Peptide : non-phospho-peptide. -
Gene Info — FOS
Entrez GeneID
2353Protein Accession#
NP_005243;P01100Gene Name
FOS
Gene Alias
AP-1, C-FOS
Gene Description
v-fos FBJ murine osteosarcoma viral oncogene homolog
Omim ID
164810Gene Ontology
HyperlinkGene Summary
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq
Other Designations
FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)|activator protein 1|cellular oncogene c-fos
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Interactome
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Pathway
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Disease
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Publication Reference
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Helicobacter pylori infection activates FOS and stress-response genes and alters expression of genes in gastric cancer-specific loci.
Myllykangas S, Monni O, Nagy B, Rautelin H, Knuutila S.
Genes, Chromosomes & Cancer 2004 Aug; 40(4):334.
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Tobacco smoke control of mucin production in lung cells requires oxygen radicals AP-1 and JNK.
Gensch E, Gallup M, Sucher A, Li D, Gebremichael A, Lemjabbar H, Mengistab A, Dasari V, Hotchkiss J, Harkema J, Basbaum C.
The Journal of Biological Chemistry 2004 Sep; 279(37):39085.
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Expression of Egr-1, c-fos and cyclin D1 in esophageal cancer and its precursors: An immunohistochemical and in situ hybridization study.
Wu MY, Zhuang CX, Yang HX, Liang YR.
World Journal of Gastroenterology 2004 Feb; 10(4):476.
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Helicobacter pylori infection activates FOS and stress-response genes and alters expression of genes in gastric cancer-specific loci.
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