AIFM1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of AIFM1 in human colon. Using AIFM1 polyclonal antibody (Cat # PAB0324) at 1 : 2000. Lane 1, normal colon. Lanes 2-7, colon carcinoma tissue lysates from 6 different patients. mAIF, thought to represent mitochondrial AIF.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of AIFM1 in formalin-fixed, paraffin-embedded normal human colon. Using AIFM1 polyclonal antibody (Cat # PAB0324) at 1 : 2000. Hematoxylin-eosin counterstain. In this example, AIFM1 expression is predominant in the upper part of the crypt.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of AIFM1.
Immunogen
A synthetic peptide corresponding to amino acids 151-169 of human AIFM1.
Sequence
RARDPGARVLIVSEDPELP
Host
Rabbit
Reactivity
Bovine, Dog, Human, Mouse, Rat
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In serum (0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of AIFM1 in human colon. Using AIFM1 polyclonal antibody (Cat # PAB0324) at 1 : 2000. Lane 1, normal colon. Lanes 2-7, colon carcinoma tissue lysates from 6 different patients. mAIF, thought to represent mitochondrial AIF.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of AIFM1 in formalin-fixed, paraffin-embedded normal human colon. Using AIFM1 polyclonal antibody (Cat # PAB0324) at 1 : 2000. Hematoxylin-eosin counterstain. In this example, AIFM1 expression is predominant in the upper part of the crypt.Immunohistochemistry (Frozen sections)
Immunoprecipitation
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Gene Info — AIFM1
Entrez GeneID
9131Protein Accession#
NP_004199.1Gene Name
AIFM1
Gene Alias
AIF, MGC111425, PDCD8
Gene Description
apoptosis-inducing factor, mitochondrion-associated, 1
Omim ID
300169Gene Ontology
HyperlinkGene Summary
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Several alternative transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000024007|OTTHUMP00000024008|OTTHUMP00000024009|programmed cell death 8|programmed cell death 8 (apoptosis-inducing factor)|striatal apoptosis-inducing factor
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Interactome
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Pathway
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Disease
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