TNF monoclonal antibody, clone 4E1
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant TNF.
Immunogen
Recombinant protein corresponding to full length human TNF.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG1
Recommend Usage
Western blot (1:1000)
Immunohistochemistry (1:10)
The optimal working dilution should be determined by the end user.Storage Buffer
In Citrate-Tris-HCl buffer, pH 7.0 (0.02% Proclin 300)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
Western Blot (Recombinant protein)
Western blot analysis of recombinant TNF protein with TNF monoclonal antibody, clone 4E1 (Cat # MAB9938) at 1:1000 dilution.Immunohistochemistry
Immunohistochemical staining of human liver cancer tissue section with TNF monoclonal antibody, clone 4E1 (Cat # MAB9938) at 1:10 dilution.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TNF
Entrez GeneID
7124GeneBank Accession#
NM_000594.2Protein Accession#
NP_000585.2Gene Name
TNF
Gene Alias
DIF, TNF-alpha, TNFA, TNFSF2
Gene Description
tumor necrosis factor (TNF superfamily, member 2)
Gene Ontology
HyperlinkGene Summary
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq
Other Designations
APC1 protein|OTTHUMP00000029281|OTTHUMP00000037669|TNF superfamily, member 2|TNF, macrophage-derived|TNF, monocyte-derived|cachectin|tumor necrosis factor alpha
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Interactome
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Pathway
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Disease
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Publication Reference
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Khasianine ameliorates psoriasis-like skin inflammation and represses TNF-α/NF-κB axis mediated transactivation of IL-17A and IL-33 in keratinocytes.
Yixi Yang, Yujin Zhang, Xun Chen, Zhou Su, Yu Deng, Qi Zhao.
Journal of Ethnopharmacology 2022 Feb; 292:115124.
Application:IHC, Mouse, Mouse skin.
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Khasianine ameliorates psoriasis-like skin inflammation and represses TNF-α/NF-κB axis mediated transactivation of IL-17A and IL-33 in keratinocytes.
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