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Last updated: 2015/8/30
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CDH1 monoclonal antibody, clone SHE78-7

  • Catalog # : MAB8362
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native CDH1.
  • Immunogen:
  • Native purified CDH1 from human placental.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • This antibody specifically reacts with human E-Cadherin, but does not react with rat E-Cadherin. This antibody inhibits E-Cadherin dependent cell-cell contact.
  • Form:
  • Lyophilized
  • Isotype:
  • IgG2a
  • Recommend Usage:
  • ELISA (2 ug/mL)
    Western Blot (2 ug/mL)
    Flow Cytometry (1 ug/mL)
    Immunohistochemistry (Frozen sections) (2 ug/mL)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2 ug/mL)
    Immunofluorescence (1 ug/mL)
    Inhibition Assay (1 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from 10 mM PBS, pH 7.4 (1% BSA)
  • Storage Instruction:
  • Store at 4°C.
    After reconstitution with deionized water, store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Frozen sections)
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescence of monoclonal antibody to CDH1 on HL-60 cell. [antibody concentration 10 ug/ml]
  • Protocol Download
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescence of monoclonal antibody to CDH1 on MCF-7 cell. [antibody concentration 10 ug/ml]
  • Protocol Download
  • ELISA
  • Inhibition Assay
  • Flow Cytometry
  • Immunofluorescence (Circulating Tumor Cell)
  • Immunofluorescence (Circulating Tumor Cell)
  • MCF-7 cells were stained with CDH1-FITC labeled monoclonal antibody (Green). The cell nucleus were counterstained with DAPI (Blue).
  • Application Image
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Frozen sections)
  • ELISA
  • Inhibition Assay
  • Flow Cytometry
  • Immunofluorescence (Circulating Tumor Cell)
  • Immunofluorescence (Circulating Tumor Cell)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 999
  • Gene Name:
  • CDH1
  • Gene Alias:
  • Arc-1,CD324,CDHE,ECAD,LCAM,UVO
  • Gene Description:
  • cadherin 1, type 1, E-cadherin (epithelial)
  • Gene Summary:
  • This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq
  • Other Designations:
  • cadherin 1, E-cadherin (epithelial),cadherin 1, type 1,calcium-dependent adhesion protein, epithelial,cell-CAM 120/80,uvomorulin
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