TNFRSF8 monoclonal antibody, clone AC10
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Mouse monoclonal antibody raised against native TNFRSF8.
Immunogen
Native purified TNFRSF8 from human YT lymphoma cells.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG2b, kappa
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C.
-
Applications
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Flow Cytometry
-
Gene Info — TNFRSF8
Entrez GeneID
943Gene Name
TNFRSF8
Gene Alias
CD30, D1S166E, KI-1
Gene Description
tumor necrosis factor receptor superfamily, member 8
Omim ID
153243Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
CD30 antigen|CD30L receptor|Ki-1 antigen|OTTHUMP00000001783|cytokine receptor CD30|lymphocyte activation antigen CD30
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Direct cellular communications between CD45R0 and CD45RA T cell subsets via CD27/CD70.
Agematsu K, Kobata T, Sugita K, Hirose T, Schlossman SF, Morimoto C.
The Journal of Immunology 1995 Apr; 154(8):3627.
Application:IF, Human, CD45RA+/CD45RO+ CD4 T cells.
-
CD30 (Ki-1) molecule: a new cytokine receptor of the tumor necrosis factor receptor superfamily as a tool for diagnosis and immunotherapy.
Falini B, Pileri S, Pizzolo G, Durkop H, Flenghi L, Stirpe F, Martelli MF, Stein H.
Blood 1995 Jan; 85(1):1.
-
Functional effects of CD30 on a large granular lymphoma cell line, YT. Inhibition of cytotoxicity, regulation of CD28 and IL-2R, and induction of homotypic aggregation.
Bowen MA, Olsen KJ, Cheng L, Avila D, Podack ER.
The Journal of Immunology 1993 Dec; 151(11):5896.
Application:IP, Human, YT cells.
-
Direct cellular communications between CD45R0 and CD45RA T cell subsets via CD27/CD70.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com