CD34 monoclonal antibody, clone QBEnd-10 (FITC)
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Specification
Product Description
Mouse monoclonal antibody raised against native CD34.
Immunogen
Native purified CD34 from human endothelial vesicles.
Host
Mouse
Theoretical MW (kDa)
110-115
Reactivity
Human, Non-Human Primates
Specificity
This antibody reacts with Class II epitope on CD34 (Mucosialin), a 110-115 KDa monomeric transmembrane phosphoglycoprotein expressed on hematopoietic progenitors cells and on the most pluripotential stem cells; it is gradually lost on progenitor cells. This antibody has been also used as an endothelial marker.
Form
Liquid
Conjugation
FITC
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — CD34
Entrez GeneID
947Gene Name
CD34
Gene Alias
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Gene Description
CD34 molecule
Omim ID
142230Gene Ontology
HyperlinkGene Summary
CD34 is a monomeric cell surface antigen with a molecular mass of approximately 110 kD that is selectively expressed on human hematopoietic progenitor cells.[supplied by OMIM
Other Designations
CD34 antigen|OTTHUMP00000034733|OTTHUMP00000034734|hematopoietic progenitor cell antigen CD34
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Interactome
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Pathway
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Disease
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Publication Reference
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Certain anti-CD34 monoclonal antibodies induce homotypic adhesion of leukemic cell lines in a CD18-dependent and a CD18-independent way.
Traore Y, Hirn J.
European Journal of Immunology 1994 Oct; 24(10):2304.
Application:Flow Cyt, Func, Human, KG-l cells.
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QBEND/10 (anti-CD34 antibody) in external root sheath cells and follicular tumors.
Poblet E, Jimenez-Acosta F, Rocamora A.
Journal of Cutaneous Pathology 1994 Jun; 21(3):224.
Application:IHC-P, Human, Human follicular tumors.
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Rapid positive selection of CD34+ cells using magnetic microspheres coated with monoclonal antibody QBEND/10 linked via a cleavable disulphide bond.
Grimsley PG, Amos TA, Gordon MY, Greaves MF.
Leukemia 1993 Jun; 7(6):898.
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Differential sensitivity of CD34 epitopes to cleavage by Pasteurella haemolytica glycoprotease: implications for purification of CD34-positive progenitor cells.
Sutherland DR, Marsh JC, Davidson J, Baker MA, Keating A, Mellors A.
Exp Hematol 1992 Jun; 20(5):590.
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Heterogeneity of vascular endothelial cells with relevance to diagnosis of vascular tumours.
Kuzu I, Bicknell R, Harris AL, Jones M, Gatter KC, Mason DY.
Journal of Clinical Pathology 1992 Feb; 45(2):143.
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Certain anti-CD34 monoclonal antibodies induce homotypic adhesion of leukemic cell lines in a CD18-dependent and a CD18-independent way.
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