Mouse monoclonal antibody raised against recombinant IFNG.
Recombinant protein corresponding to human IFNG.
human Interferon-gamma (IFN-gamma)1-2. This is a neutralizing antibody. B27 monoclonal antibody has been used for epitope mapping of human IFN-gamma1. The B27 antibody does not bind to denatured IFN-gamma1.
The optimal working dilution should be determined by the end user.
In PBS (0.1 mg/mL sodium azide)
Store at 4°C. Do not freeze.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Interferon-gamma (IFNG), or type II interferon, is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFNG expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFNG in the immune system stems in part from its ability to inhibit viral replication directly, but most importantly derives from its immunostimulatory and immunomodulatory effects. IFNG is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 (MIM 186940) and CD8 (see MIM 186910) cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops (Schoenborn and Wilson, 2007 [PubMed 17981204]).[supplied by OMIM