BCL10 monoclonal antibody, clone 4F8E8H8
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of MCF-7 cell extracts with BCL10 monoclonal antibody, clone 4F8E8H8 (Cat # MAB5567).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma (A) and liver carcinoma (B) tissue, showing cytoplasmical localization, using BCL10 monoclonal antibody, clone 4F8E8H8 (Cat # MAB5567) with DAB staining.
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant BCL10.
Immunogen
Recombinant protein corresponding to BCL10.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Western Blot (1:2000-1:5000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100-1:500)
Immunohistochemistry (Frozen sections) (1:200-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of MCF-7 cell extracts with BCL10 monoclonal antibody, clone 4F8E8H8 (Cat # MAB5567).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma (A) and liver carcinoma (B) tissue, showing cytoplasmical localization, using BCL10 monoclonal antibody, clone 4F8E8H8 (Cat # MAB5567) with DAB staining.Immunohistochemistry (Frozen sections)
Enzyme-linked Immunoabsorbent Assay
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Gene Info — BCL10
Entrez GeneID
8915Gene Name
BCL10
Gene Alias
CARMEN, CIPER, CLAP, c-E10, mE10
Gene Description
B-cell CLL/lymphoma 10
Omim ID
603517Gene Ontology
HyperlinkOther Designations
CARD containing molecule enhancing NF-kB|CARD-containing apoptotic signaling protein|CARD-containing proapoptotic protein|CARD-like apoptotic protein|OTTHUMP00000011647|OTTHUMP00000036080|caspase-recruiting domain-containing protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway.
Lucas PC, Yonezumi M, Inohara N, McAllister-Lucas LM, Abazeed ME, Chen FF, Yamaoka S, Seto M, Nunez G.
The Journal of Biological Chemistry 2001 Jun; 276(22):19012.
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Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B.
Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J.
The Journal of Biological Chemistry 2001 Jun; 276(24):21405.
Application：IP-WB, WB-Ce, WB-Tr, Human, 293T cells.
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Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types.
Willis TG, Jadayel DM, Du MQ, Peng H, Perry AR, Abdul-Rauf M, Price H, Karran L, Majekodunmi O, Wlodarska I, Pan L, Crook T, Hamoudi R, Isaacson PG, Dyer MJ.
Cell 1999 Jan; 96(1):35.
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Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway.
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