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BIOtech
BULK-new

CD27 monoclonal antibody, clone CLB-27

  • Catalog # : MAB5255
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native CD27.
  • Immunogen:
  • Native purified CD27 from human E-rossette positive lymphocytes.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • The monoclonal antibody is directed against the CD27 antigen, a 55 kD protein, which is expressed on a large subpopulation (75%) of peripheral blood T-lymphocytes and most medullary thymocytes. Little binding was observed with normal human B-cells, CD3 negative leukemic cells, B-cells derived and myeloid leukemias.
  • Form:
  • Liquid
  • Isotype:
  • IgG2a
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 20 mM Tris, 150 mM NaCl, pH 8.0 (10 mg BSA, 0.001% thimerosal)
  • Storage Instruction:
  • Store at 4°C.
  • Note:
  • This product contains thimerosal: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunofluorescence
  • Flow Cytometry
  • Application Image
  • Immunofluorescence
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 939
  • Gene Name:
  • CD27
  • Gene Alias:
  • MGC20393,S152,T14,TNFRSF7,Tp55
  • Gene Description:
  • CD27 molecule
  • Gene Summary:
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq
  • Other Designations:
  • CD27 antigen,CD27L receptor,T cell activation antigen CD27,T cell antivation antigen S152,tumor necrosis factor receptor superfamily, member 7
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