Mouse monoclonal antibody raised against native CD27.
Native purified CD27 from human E-rossette positive lymphocytes.
The monoclonal antibody is directed against the CD27 antigen, a 55 kD protein, which is expressed on a large subpopulation (75%) of peripheral blood T-lymphocytes and most medullary thymocytes. Little binding was observed with normal human B-cells, CD3 negative leukemic cells, B-cells derived and myeloid leukemias.
The optimal working dilution should be determined by the end user.
In 20 mM Tris, 150 mM NaCl, pH 8.0 (10 mg BSA, 0.001% thimerosal)
Store at 4°C.
This product contains thimerosal: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq