BCAM monoclonal antibody, clone BRIC221
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Specification
Product Description
Mouse monoclonal antibody raised against native BCAM.
Immunogen
Native purified BCAM from human erythrocytes.
Host
Mouse
Reactivity
Human
Specificity
This antibody recognizes a non-polymorphic determinant on both the 85 and 78kD Lutheran (Lu) glycoproteins. BRIC 221 specifically recognizes an epitope in the fourth extracellular domain of Lu glycoprotein. CD239 is expressed by erythrocytes in the peripheral blood.
Form
Liquid
Isotype
IgG2b
Recommend Usage
Flow Cytometry (10ul of the suggested working dilution to label 106 cells or 100ul)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.5 (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Flow Cytometry
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Gene Info — BCAM
Entrez GeneID
4059Gene Name
BCAM
Gene Alias
AU, CD239, LU, MSK19
Gene Description
basal cell adhesion molecule (Lutheran blood group)
Omim ID
111200Gene Ontology
HyperlinkGene Summary
Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
Auberger b antigen|B-CAM cell surface glycoprotein|B-cell adhesion molecule|F8/G253 antigen|Lutheran blood group (Auberger b antigen included)|antigen identified by monoclonal antibody F8|basal cell adhesion molecule|basal cell adhesion molecule (Lu and A
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Interactome
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Disease
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