Mouse monoclonal antibody raised against native TNFRSF8.
Native purified TNFRSF8 from human Co cells.
Clone Ber-H2 distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45). Does not react with baboon or monkey. Molecular weight: 120 KDa (mature), 95 KDa (precursor).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:40-1:80) The optimal working dilution should be determined by the end user.
In tissue culture supernatant (0.09% sodium azide)
Store at 4°C.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq