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FASLG monoclonal antibody, clone 4A5

  • Catalog # : MAB4703
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  • Specification
  • Product Description:
  • Hamster monoclonal antibody raised against recombinant FASLG.
  • Immunogen:
  • Recombinant protein corresponding to human FASLG.
  • Host:
  • Hamster
  • Reactivity:
  • Human
  • Specificity:
  • Apoptosis or programmed-cell death is a physiological process essential for the normal development and maintenance or homeostasis in many organisms. This "cellular suicide" can be triggered by the interaction of two cell-surface molecules, the Fas antigen (CD95) and its ligand, the Fas ligand or FasL.(1) The FasL is a type II membrane protein of M, 40KDa and is a member of the tumor necrosis factor (TNF) family.(2,3) It is expressed by activated T cells.(4) A 26KDa soluble form of human FasL (sFasL) exists and has been detected in the supernatant of human peripheral NK cells (5) and lymphocytes (6) upon activation. Reacts with human FasL specifically.(5) Cross-reactivity with other species has not been tested yet. Not suitable for immunoblotting.
  • Form:
  • Lyophilized
  • Isotype:
  • IgG
  • Recommend Usage:
  • Flow Cytometry (10 ug/mL as a final concentration)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from PBS
  • Storage Instruction:
  • Store at 4°C on dry atmosphere.
    After reconstitution with deionized water, store at -20°C or lower.
    Aliquot to avoid repeated freezing and thawing.
  • Publication Reference
  • 2.
  • Fas ligand in human serum.
    Tanaka M, Suda T, Haze K, Nakamura N, Sato K, Kimura F, Motoyoshi K, Mizuki M, Tagawa S, Ohga S, Hatake K, Drummond AH, Nagata S.Nat Med. 1996 Mar;2(3):317-22.
  • Applications
  • Flow Cytometry
  • Application Image
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 356
  • Gene Name:
  • Gene Alias:
  • Gene Description:
  • Fas ligand (TNF superfamily, member 6)
  • Gene Summary:
  • The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). [provided by RefSeq
  • Other Designations:
  • CD95 ligand,OTTHUMP00000032708,apoptosis (APO-1) antigen ligand 1,fas ligand,tumor necrosis factor (ligand) superfamily, member 6
  • Interactome
  • Interactome
  • Related Disease
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