Hamster monoclonal antibody raised against recombinant FASLG.
Recombinant protein corresponding to human FASLG.
Apoptosis or programmed-cell death is a physiological process essential for the normal development and maintenance or homeostasis in many organisms. This "cellular suicide" can be triggered by the interaction of two cell-surface molecules, the Fas antigen (CD95) and its ligand, the Fas ligand or FasL.(1) The FasL is a type II membrane protein of M, 40KDa and is a member of the tumor necrosis factor (TNF) family.(2,3) It is expressed by activated T cells.(4) A 26KDa soluble form of human FasL (sFasL) exists and has been detected in the supernatant of human peripheral NK cells (5) and lymphocytes (6) upon activation. Reacts with human FasL specifically.(5) Cross-reactivity with other species has not been tested yet. Not suitable for immunoblotting.
Flow Cytometry (10 ug/mL as a final concentration) The optimal working dilution should be determined by the end user.
Lyophilized from PBS
Store at 4°C on dry atmosphere. After reconstitution with distilled water, store at -20°C. Aliquot to avoid repeated freezing and thawing.
The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). [provided by RefSeq