CD34 monoclonal antibody, clone 4H11[APG] (FITC)
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More Files
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Flow Cytometry
Surface staining of KG-1a (human acute myelogenous leukemia cell line) with CD34 monoclonal antibody, clone 4H11[APG] (FITC) (Cat # MAB4412). Total viable cells were used for analysis.
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Specification
Product Description
Mouse monoclonal antibody raised against native CD34.
Immunogen
Native purified CD34 from permanent human cell line derived from peripheral leucocytes of a patient suffering from chronic myeloid leukaemia.
Host
Mouse
Theoretical MW (kDa)
110-115
Reactivity
Human
Specificity
This antibody reacts with Class III epitope on CD34 (Mucosialin), a 110-115 KDa monomeric transmembrane phosphoglycoprotein expressed on hematopoietic progenitors cells and on the most pluripotential stem cells; it is gradually lost on progenitor cells.
Form
Liquid
Conjugation
FITC
Isotype
IgG1
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Flow Cytometry
Surface staining of KG-1a (human acute myelogenous leukemia cell line) with CD34 monoclonal antibody, clone 4H11[APG] (FITC) (Cat # MAB4412). Total viable cells were used for analysis. -
Gene Info — CD34
Entrez GeneID
947Gene Name
CD34
Gene Alias
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Gene Description
CD34 molecule
Omim ID
142230Gene Ontology
HyperlinkGene Summary
CD34 is a monomeric cell surface antigen with a molecular mass of approximately 110 kD that is selectively expressed on human hematopoietic progenitor cells.[supplied by OMIM
Other Designations
CD34 antigen|OTTHUMP00000034733|OTTHUMP00000034734|hematopoietic progenitor cell antigen CD34
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Interactome
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Pathway
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Disease
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Publication Reference
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Hematopoietic stem cell antigen CD34: role in adhesion or homing.
Gangenahalli GU, Singh VK, Verma YK, Gupta P, Sharma RK, Chandra R, Luthra PM.
Stem Cells and Development 2006 Jun; 15(3):305.
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Three-dimensional structure prediction of the interaction of CD34 with the SH3 domain of Crk-L.
Gangenahalli GU, Singh VK, Verma YK, Gupta P, Sharma RK, Chandra R, Gulati S, Luthra PM.
Stem Cells and Development 2005 Oct; 14(5):470.
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Reversibility of CD34 expression on human hematopoietic stem cells that retain the capacity for secondary reconstitution.
Dao MA, Arevalo J, Nolta JA.
Blood 2002 Jul; 101(1):112.
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Hematopoietic stem cell antigen CD34: role in adhesion or homing.
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