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Last updated: 2014/4/14
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BIOtech
BULK-new

HLA Class I monoclonal antibody, clone MEM-123

  • Catalog # : MAB3854
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native HLA Class I.
  • Immunogen:
  • Native purified HLA Class I from African Green Monkey COS-7 cells.
  • Host:
  • Mouse
  • Reactivity:
  • Bovine, Human
  • Specificity:
  • This antibody reacts with all human classical MHC Class I molecules (majorhistocompatibility complex) in native cell-surface forms as well as with human HLA-G cDNA transfected cells. MHC Class I molecules (MHC Class Ia) are expressed on the surface ofall human cell types.This antibody completely blocks binding of classical W6/32 to surface-expressed HLA-G, but does not cross-blocks this antibody.
  • Form:
  • Liquid
  • Concentration:
  • 1 mg/mL
  • Isotype:
  • IgG3
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In TBS, pH 8.0 (15 mM sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunoprecipitation
  • ELISA
  • Flow Cytometry
  • Application Image
  • Immunoprecipitation
  • ELISA
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 3105
  • Gene Name:
  • HLA-A
  • Gene Alias:
  • HLAA
  • Gene Description:
  • major histocompatibility complex, class I, A
  • Gene Summary:
  • HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq
  • Other Designations:
  • HLA class I histocompatibility antigen, A-23 alpha chain,MHC class I antigen HLA-A heavy chain,MHC leukocyte antigen,OTTHUMP00000161059,antigen presenting molecule,leucocyte antigen class I,leukocyte antigen class I-A
  • Gene Information
  • Entrez GeneID:
  • 3133
  • Gene Name:
  • HLA-E
  • Gene Alias:
  • DKFZp686P19218,EA1.2,EA2.1,HLA-6.2,MHC,QA1
  • Gene Description:
  • major histocompatibility complex, class I, E
  • Gene Summary:
  • HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq
  • Other Designations:
  • HLA class I histocompatibility antigen, E alpha chain,MHC HLA-E alpha-1,MHC HLA-E alpha-2.1,MHC class I antigen,OTTHUMP00000029214,lymphocyte antigen
  • Gene Information
  • Entrez GeneID:
  • 3134
  • Gene Name:
  • HLA-F
  • Gene Alias:
  • CDA12,HLA-5.4,HLA-CDA12,HLAF
  • Gene Description:
  • major histocompatibility complex, class I, F
  • Gene Summary:
  • This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq
  • Other Designations:
  • HLA class I molecule,MHC class I antigen,MHC class Ib antigen,OTTHUMP00000109209,OTTHUMP00000109210,OTTHUMP00000109211,leukocyte antigen F
  • Gene Information
  • Entrez GeneID:
  • 3135
  • Gene Name:
  • HLA-G
  • Gene Alias:
  • MHC-G
  • Gene Description:
  • major histocompatibility complex, class I, G
  • Gene Summary:
  • HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq
  • Other Designations:
  • HLA class I molecule,HLA-G histocompatibility antigen, class I, G,MHC class I antigen,OTTHUMP00000039485,b2 microglobulin
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