Rat monoclonal antibody raised against recombinant IL4.
Recombinant protein corresponding to human IL4.
human Interleukin-4 (IL-4) The MP4-25D2 antibody has been reported to cross react with IL-4 from Rhesus monkeys. This antibody has also been reported to be useful for epitope mapping of human IL-4.2 This is a neutralizing antibody.
Western Blot (1-5 ug/mL) The optimal working dilution should be determined by the end user.
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq