BIRC5 monoclonal antibody, clone 32.1
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant BIRC5.
Immunogen
Recombinant protein corresponding to full length human BIRC5.
Host
Mouse
Reactivity
Human
Specificity
This antibody is specific to the nuclear form of survivin. The epitope recognized is between amino acids 3-19.
Form
Liquid
Isotype
IgG1, kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (20 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry
Staining of human lung, cancer using BIRC5 monoclonal antibody, clone 32.1 (Cat # MAB2365).Immunofluorescence
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Gene Info — BIRC5
Entrez GeneID
332Protein Accession#
O15392Gene Name
BIRC5
Gene Alias
API4, EPR-1
Gene Description
baculoviral IAP repeat-containing 5
Omim ID
603352Gene Ontology
HyperlinkGene Summary
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq
Other Designations
apoptosis inhibitor 4|baculoviral IAP repeat-containing protein 5|survivin variant 3 alpha
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Interactome
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Pathway
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Disease
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Publication Reference
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Emerging role for autophagy in the removal of aggresomes in Schwann cells.
Fortun J, Dunn WA Jr, Joy S, Li J, Notterpek L.
The Journal of Neuroscience 2003 Nov; 23(33):10672.
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Regulation of microtubule stability and mitotic progression by survivin.
Giodini A, Kallio MJ, Wall NR, Gorbsky GJ, Tognin S, Marchisio PC, Symons M, Altieri DC.
Cancer Research 2002 May; 62(9):2462.
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Emerging role for autophagy in the removal of aggresomes in Schwann cells.
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