CDKN2B monoclonal antibody, clone DCS114.1
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant CDKN2B.
Immunogen
Recombinant protein corresponding to full length human CDKN2B.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Western blot (1 to 5 ug /mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
Immunoprecipitation
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Gene Info — CDKN2B
Entrez GeneID
1030Gene Name
CDKN2B
Gene Alias
CDK4I, INK4B, MTS2, P15, TP15, p15INK4b
Gene Description
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Omim ID
600431Gene Ontology
HyperlinkGene Summary
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq
Other Designations
CDK inhibitory protein|CDK4B inhibitor|OTTHUMP00000021154|OTTHUMP00000021155|cyclin-dependent kinase 4 inhibitor B|cyclin-dependent kinase inhibitor 2B|cyclin-dependent kinases 4 and 6 binding protein|multiple tumor suppressor 2|p14_CDK inhibitor|p14_INK4
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Interactome
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Pathway
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Disease
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Publication Reference
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Inhibitors of mammalian G1 cyclin-dependent kinases.
Sherr CJ, Roberts JM.
Genes & Development 1995 May; 9(10):1149.
Application:IHC, WB-Ce, WN-Ti, WB-Tr, Human, Mouse, HaCaT cells, Lungs, Mammalian cells, Spleens.
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Inhibitors of mammalian G1 cyclin-dependent kinases.
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