MMP1 monoclonal antibody, clone 3B6
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More Files
- More Functions
Western Blot (Recombinant protein)
Western blot using MMP1 monoclonal antibody, clone 3B6 (Cat # MAB1950) on recombinant human MMP1 proenzyme (400 ng/lane).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining using MMP1 monoclonal antibody, clone 3B6 (Cat # MAB1950) on human colon carcinoma tissue section.
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of MMP1.
Immunogen
A synthetic peptide corresponding to C-terminus of human MMP1.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western blot (1 to 2 ug/mL)
Immunohistochemistry on formalin to fixed/paraffin to embedded tissues (1 to 5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot using MMP1 monoclonal antibody, clone 3B6 (Cat # MAB1950) on recombinant human MMP1 proenzyme (400 ng/lane).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining using MMP1 monoclonal antibody, clone 3B6 (Cat # MAB1950) on human colon carcinoma tissue section. -
Gene Info — MMP1
Entrez GeneID
4312Gene Name
MMP1
Gene Alias
CLG, CLGN
Gene Description
matrix metallopeptidase 1 (interstitial collagenase)
Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq
Other Designations
fibroblast collagenase|interstitial collagenase|matrix metalloprotease 1|matrix metalloproteinase 1|matrix metalloproteinase 1 (interstitial collagenase)
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Interactome
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Pathway
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Disease
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Publication Reference
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Anti-tumour necrosis factor (TNF)-alpha therapy (etanercept) down-regulates serum matrix metalloproteinase (MMP)-3 and MMP-1 in rheumatoid arthritis.
Catrina AI, Lampa J, Ernestam S, af Klint E, Bratt J, Klareskog L, Ulfgren AK.
Rheumatology (Oxford, England) 2002 May; 41(5):484.
Application：ELISA, IHC-Fr, Human, Serum, Human synovial biopsies.
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Utility of MMP-1, p53, E-cadherin, and collagen IV immunohistochemical stains in the differential diagnosis of adenomas with misplaced epithelium versus adenomas with invasive adenocarcinoma.
Yantiss RK, Bosenberg MW, Antonioli DA, Odze RD.
The American Journal of Surgical Pathology 2002 Feb; 26(2):206.
Application：IHC-P, Human, Tumors from Patients with adenomatous and carcinomatous epithelium.
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Anti-tumour necrosis factor (TNF)-alpha therapy (etanercept) down-regulates serum matrix metalloproteinase (MMP)-3 and MMP-1 in rheumatoid arthritis.
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