CDKN1B monoclonal antibody, clone SX53G8
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Specification
Product Description
Mouse monoclonal antibody raised against CDKN1B.
Immunogen
Recombinant GST fusion protein corresponding to human CDKN1B.
Host
Mouse
Reactivity
Human, Monkey, Mouse, Rat
Form
Liquid
Purification
Protein A/G affinity chromatography
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/million cells)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (0.5-1 ug/mL for 30 min at RT)
Immunoprecipitation (0.5-1 ug/500 ug protein lysate)
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.05% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
Immunofluorescence
Immunoprecipitation
Flow Cytometry
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Gene Info — CDKN1B
Entrez GeneID
1027Gene Name
CDKN1B
Gene Alias
CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Gene Description
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Gene Ontology
HyperlinkGene Summary
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq
Other Designations
cyclin-dependent kinase inhibitor 1B
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Interactome
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Pathway
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Disease
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