Western blot analysis of cell lysates of HepG2 (60 ug) and Ramos (60 ug) were resolved by SDS - PAGE , transferred to NC membrane and probed with AICDA monoclonal antibody , clone 2D3 (1 : 500) (Cat # MAB1107). Proteins were visualized using a goat anti - mouse secondary antibody conjugated to HRP and an ECL detection system.
This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq
activation-induced deaminase,integrated into Burkitt's lymphoma cell line Ramos