AGT monoclonal antibody, clone 1B1
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant AGT.
Immunogen
Recombinant protein corresponding to human AGT.
Host
Mouse
Theoretical MW (kDa)
53
Reactivity
Human
Form
Liquid
Isotype
IgG2b
Recommend Usage
Western Blot (1:500-1:2000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In ascitic (0.03% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis using AGT monoclonal antibody, clone 1B1 (Cat # MAB10442) against human plasma (1).Enzyme-linked Immunoabsorbent Assay
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Gene Info — AGT
Entrez GeneID
183Gene Name
AGT
Gene Alias
ANHU, FLJ92595, FLJ97926, SERPINA8
Gene Description
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq
Other Designations
OTTHUMP00000035878|alpha-1 antiproteinase, antitrypsin|angiotensin I|angiotensin II|angiotensinogen|pre-angiotensinogen|serine (or cysteine) proteinase inhibitor
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Interactome
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Pathway
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Disease
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