CD27 monoclonal antibody, clone LT27
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More Files
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Flow Cytometry
Surface staining of human peripheral blood cells with CD27 monoclonal antibody, clone LT27 (Cat # MAB0923) PE. Cells in the lymphocyte gate were used for analysis.
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Specification
Product Description
Mouse monoclonal antibody raised against native CD27.
Immunogen
Native purified CD27 from human peripheral blood lymphocytes.
Host
Mouse
Theoretical MW (kDa)
50-55
Reactivity
Human
Specificity
This antibody reacts with CD27 (T14), a 50-55 KDa type I transmembrane glycoprotein (member of the TNF-receptor superfamily) expressed on medullary thymocytes, peripheral T lymphocytes, some B lymphocytes and NK cells.
Form
Liquid
Purification
Protein-A affinity chromatography.
Isotype
IgG2a
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Surface staining of human peripheral blood cells with CD27 monoclonal antibody, clone LT27 (Cat # MAB0923) PE. Cells in the lymphocyte gate were used for analysis. -
Gene Info — CD27
Entrez GeneID
939Gene Name
CD27
Gene Alias
MGC20393, S152, T14, TNFRSF7, Tp55
Gene Description
CD27 molecule
Omim ID
186711Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq
Other Designations
CD27 antigen|CD27L receptor|T cell activation antigen CD27|T cell antivation antigen S152|tumor necrosis factor receptor superfamily, member 7
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Interactome
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Pathway
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Disease
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