Immunoprecipitation of ATG16L1 transfected lysate using anti-ATG16L1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with ATG16L1 purified MaxPab mouse polyclonal antibody (B01P) (H00055054-B01P).
Autophagy is the major intracellular degradation system delivering cytoplasmic components to lysosomes, and it accounts for degradation of most long-lived proteins and some organelles. Cytoplasmic constituents, including organelles, are sequestered into double-membraned autophagosomes, which subsequently fuse with lysosomes. ATG16L1 is a component of a large protein complex essential for autophagy (Mizushima et al., 2003 [PubMed 12665549]).[supplied by OMIM
APG16 autophagy 16-like,APG16L beta,ATG16 autophagy related 16-like protein 1,WD repeat domain 30