TCIRG1 monoclonal antibody (M01), clone 6H3
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More Files
- More Functions
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant TCIRG1.
Immunogen
TCIRG1 (AAH18133, 121 a.a. ~ 220 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
QLHQLQLHAAVLRQGHEPQLAAAHTDGASERTPLLQAPGGPHQDLRVNFVAGAVEPHKAPALERLLWRACRGFLIASFRELEQPLEHPVTGEPATWMTFL
Host
Mouse
Reactivity
Human
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — TCIRG1
Entrez GeneID
10312GeneBank Accession#
BC018133Protein Accession#
AAH18133Gene Name
TCIRG1
Gene Alias
ATP6N1C, ATP6V0A3, Atp6i, OC-116kDa, OC116, OPTB1, Stv1, TIRC7, Vph1, a3
Gene Description
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
Gene Ontology
HyperlinkGene Summary
Through alternate splicing, this gene encodes two proteins with similarity to subunits of the vacuolar ATPase (V-ATPase) but the encoded proteins seem to have different functions. V-ATPase is a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq
Other Designations
ATPase, H+ transporting, 116kD|T cell immune response cDNA7 protein|T-cell immune regulator 1|T-cell, immune regulator 1|T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3|T-cell, immune regulator 1, ATPase, H+ transporting, lyso
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Interactome
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Pathway
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Disease
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Publication Reference
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Generation of Gene-Corrected Functional Osteoclasts From Osteopetrotic Induced Pluripotent Stem Cells.
Xiaojie Xian, Roksana Moraghebi, Henrik Löfvall, Anders Fasth, Kim Henriksen, Johan Richter, Niels-Bjarne Woods, Ilana Moscatelli.
Stem Cell Research & Therapy 2020 May; 11(1):179.
Application:WB-Ce, Human, Induced pluripotent stem cells.
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Expanded circulating hematopoietic stem/progenitor cells as novel cell source for the treatment of TCIRG1 osteopetrosis.
Capo V, Penna S, Merelli I, Barcella M, Scala S, Basso-Ricci L, Draghici E, Palagano E, Zonari E, Desantis G, Uva P, Cusano R, Sergi Sergi L, Crisafulli L, Moshous D, Stepensky P, Drabko K, Kaya Z, Unal E, Gezdirici A, Menna G, Serafini M, Aiuti A, Locatelli SL, Carlo-Stella C, Schulz AS, Ficara F, Sobacchi C, Gentner B, Villa A.
Haematologica 2021 Jan; 106(1):74.
Application:WB-Ce, Human, Human osteoclasts.
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A specific subtype of osteoclasts secretes factors inducing nodule formation by osteoblasts.
Henriksen K, Andreassen KV, Thudium CS, Gudmann KN, Moscatelli I, Crüger-Hansen CE, Schulz AS, Dziegiel MH, Richter J, Karsdal MA, Neutzsky-Wulff AV.
Bone 2012 Jul; 51(3):353.
Application:WB, Human, Osteoblasts from IMO patients.
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Impaired gastric acidification negatively affects calcium homeostasis and bone mass.
Schinke T, Schilling AF, Baranowsky A, Seitz S, Marshall RP, Linn T, Blaeker M, Huebner AK, Schulz A, Simon R, Gebauer M, Priemel M, Kornak U, Perkovic S, Barvencik F, Beil FT, Del Fattore A, Frattini A, Streichert T, Pueschel K, Villa A, Debatin KM, Rueg.
Nature Medicine 2009 Jun; 15(6):674.
Application:IHC, Human, Human tissues microarray.
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Differential Localization of Vacuolar H+-ATPases Containing a1, a2, a3, or a4 (ATP6V0A1-4) Subunit Isoforms Along the Nephron.
Schulz N, Dave MH, Stehberger PA, Chau T, Wagner CA.
Cellular Physiology and Biochemistry 2007 Jan; 20(1-4):109.
Application:IHC-Fr, WB-Ti, Mouse, Mouse brain, kidney.
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Generation of Gene-Corrected Functional Osteoclasts From Osteopetrotic Induced Pluripotent Stem Cells.
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