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BIOtech
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GIT2 Pre-design Chimera RNAi

  • Catalog # : H00009815-R03
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Homo sapiens G protein-coupled receptor kinase interactor 2 (GIT2), transcript variant 4, mRNA.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_139201
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Entrez GeneID:
  • 9815
  • Gene Name:
  • GIT2
  • Gene Alias:
  • CAT-2,DKFZp686G01261,KIAA0148,MGC760
  • Gene Description:
  • G protein-coupled receptor kinase interacting ArfGAP 2
  • Gene Summary:
  • This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq
  • Other Designations:
  • ARF GTPase-activating protein GIT2,G protein-coupled receptor kinase interactor 2,GRK-interacting protein 2,cool-associated, tyrosine phosphorylated protein 2
  • Gene Pathway
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