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Last updated: 2014/4/21
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BIOtech
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GIT2 MaxPab mouse polyclonal antibody (B01)MaxPab

  • Catalog # : H00009815-B01
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  • Specification
  • Product Description:
  • Mouse polyclonal antibody raised against a full-length human GIT2 protein.
  • Immunogen:
  • GIT2 (NP_631940, 1 a.a. ~ 471 a.a) full-length human protein.
  • Sequence:
  • MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPDHKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDMYDEVDRRETDAVWLATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDSDLSDGPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKLLGKDAN
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Antibody reactive against mammalian transfected lysate.
  • Storage Buffer:
  • No additive
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • For IHC and IF applications, antibody purification with Protein A will be needed prior to use.
  • Applications
  • Flow Cytometry
  • Flow Cytometry enlargeenlarge this image
  • FACS analysis of negative control 293 cells (Black) and GIT2 expressing 293 cells (Green) using GIT2 purified MaxPab mouse polyclonal antibody.
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • GIT2 MaxPab polyclonal antibody. Western Blot analysis of GIT2 expression in human pancreas.
  • Protocol Download
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • Western Blot analysis of GIT2 expression in transfected 293T cell line (H00009815-T01) by GIT2 MaxPab polyclonal antibody.

    Lane 1: GIT2 transfected lysate(51.81 KDa).
    Lane 2: Non-transfected lysate.
  • Protocol Download
  • Detection Antibody
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • Detection Antibody
  • Gene Information
  • Entrez GeneID:
  • 9815
  • Gene Name:
  • GIT2
  • Gene Alias:
  • CAT-2,DKFZp686G01261,KIAA0148,MGC760
  • Gene Description:
  • G protein-coupled receptor kinase interacting ArfGAP 2
  • Gene Summary:
  • This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq
  • Other Designations:
  • ARF GTPase-activating protein GIT2,G protein-coupled receptor kinase interactor 2,GRK-interacting protein 2,cool-associated, tyrosine phosphorylated protein 2
  • Gene Pathway
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