VRK1 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
VRK1 transfected lysate.
Western Blot
Lane 1: VRK1 transfected lysate ( 45.50 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-VRK1 full-length
Host
Human
Theoretical MW (kDa)
45.5
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-VRK1 antibody (H00007443-D01P) by Western Blots.
SDS-PAGE Gel
VRK1 transfected lysate.
Western Blot
Lane 1: VRK1 transfected lysate ( 45.50 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — VRK1
Entrez GeneID
7443GeneBank Accession#
NM_003384.2Protein Accession#
NP_003375.1Gene Name
VRK1
Gene Alias
MGC117401, MGC138280, MGC142070
Gene Description
vaccinia related kinase 1
Omim ID
602168Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq
Other Designations
vaccinia virus B1R-related kinase 1|vaccinia-related kinase-1
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