HLA-DMB (Human) IP-WB Antibody Pair
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More Files
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Immunoprecipitation of HLA-DMB transfected lysate using mouse monoclonal anti-HLA-DMB and Protein A Magnetic Bead (U0007), and immunoblotted with rabbit polyclonal anti-HLA-DMB.
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Specification
Product Description
This IP-WB antibody pair set comes with one antibody for immunoprecipitation and another to detect the precipitated protein in western blot.
Reactivity
Human
Quality Control Testing
Immunoprecipitation-Western Blot (IP-WB)
Immunoprecipitation of HLA-DMB transfected lysate using mouse monoclonal anti-HLA-DMB and Protein A Magnetic Bead (U0007), and immunoblotted with rabbit polyclonal anti-HLA-DMB.
Supplied Product
Antibody pair set content:
1. Antibody pair for IP: mouse monoclonal anti-HLA-DMB (300 ug)
2. Antibody pair for WB: rabbit polyclonal anti-HLA-DMB (50 ul)
Storage Instruction
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
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Applications
Immunoprecipitation-Western Blot
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Gene Info — HLA-DMB
Entrez GeneID
3109Gene Name
HLA-DMB
Gene Alias
D6S221E, RING7
Gene Description
major histocompatibility complex, class II, DM beta
Omim ID
142856Gene Ontology
HyperlinkGene Summary
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq
Other Designations
MHC class II HLA-DMB|MHC class II antigen HLA-DM beta chain|OTTHUMP00000029257|class II histocompatibility antigen, M beta chain
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Interactome
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Pathway
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Disease
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