FASN monoclonal antibody (M02), clone 3B3-1D6
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More Files
- More Functions
Western Blot (Tissue lysate)
FASN monoclonal antibody (M02), clone 3B3-1D6. Western Blot analysis of FASN expression in human pancreas.
Western Blot (Transfected lysate)
Western Blot analysis of FASN expression in transfected 293T cell line by FASN monoclonal antibody (M02), clone 3B3-1D6.
Lane 1: FASN transfected lysate(48.3 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of monoclonal antibody to FASN on HeLa cell . [antibody concentration 10 ug/ml]
Western Blot detection against Immunogen (74.03 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant FASN.
Immunogen
FASN (AAH07909, 1 a.a. ~ 439 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MSTNDTIVSGTLPQRMASCLEVLDLFLNQPHMVLSSFVLAEKAAAYRDRDSQRDLVEAVAHILGIRDLAAVNLDSSLADLGLDSLMSVEVRQTLERELNLVLSVREVRQLTLRKLQELSSKADEASELACPTPKEDGLAQQQTQLNLRSLLVNPEGPTLMRLNSVQSSERPLFLVHPIEGSTTVFHSLASGLSIPTYGLQCTRAAPLDSIHSLAAYYIDCIRQVQPEGPYRVAGYSYGACVAFEMCSQLQAQQSPAPTHNSLFLFDGSPTYVLAYTQSYRAKLTPGCEAEAETEAICFFVQQFTDMEHNRVLEALLPLKGLEERVAAAVDLIIKSHQGLDRQELSFAARSFYYKLRAAEQYTPKAKYHGNVMLLRAKTGGAYGEDLGADYNLSQVCDGKVSVHVIEGDHRTLLEGSGLESIISIIHSSLAEPRVSVREG
Host
Mouse
Reactivity
Human
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (74.03 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
FASN monoclonal antibody (M02), clone 3B3-1D6. Western Blot analysis of FASN expression in human pancreas.Western Blot (Transfected lysate)
Western Blot analysis of FASN expression in transfected 293T cell line by FASN monoclonal antibody (M02), clone 3B3-1D6.
Lane 1: FASN transfected lysate(48.3 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to FASN on HeLa cell . [antibody concentration 10 ug/ml] -
Gene Info — FASN
Entrez GeneID
2194GeneBank Accession#
BC007909Protein Accession#
AAH07909Gene Name
FASN
Gene Alias
FAS, MGC14367, MGC15706, OA-519, SDR27X1
Gene Description
fatty acid synthase
Omim ID
600212Gene Ontology
HyperlinkGene Summary
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq
Other Designations
short chain dehydrogenase/reductase family 27X, member 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Circulating fatty acid synthase: an exploratory biomarker to predict efficacy of the dual HER1/HER2 tyrosine kinase inhibitor lapatinib.
Oliveras-Ferraros C, Cufí S, Sauri-Nadal T, Del Barco S, Martin-Castillo B, Vazquez-Martin A, Menendez JA.
Breast Cancer Research 2011 Jan; 13(1):401.
Application：WB, Human, SKBR3 cells.
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AMPK-sensed cellular energy state regulates the release of extracellular Fatty Acid Synthase.
Oliveras-Ferraros C, Vazquez-Martin A, Fernandez-Real JM, Menendez JA.
Biochemical and Biophysical Research Communications 2008 Nov; 378(3):488.
Application：WB, Human, SK-BR-3 cells.
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Circulating fatty acid synthase: an exploratory biomarker to predict efficacy of the dual HER1/HER2 tyrosine kinase inhibitor lapatinib.
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