Products

Western Blot (Transfected lysate)

Immunoprecipitation

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

F8

Gene Alias

AHF, DXS1253E, F8B, F8C, FVIII, HEMA

Gene Description

coagulation factor VIII, procoagulant component

Omim ID

Gene Ontology

Gene Summary

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq

Other Designations

OTTHUMP00000061446|OTTHUMP00000196174|coagulation factor VIII|coagulation factor VIIIc|factor VIII F8B|procoagulant component