DMPK 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-DMPK full-length
Host
Human
Theoretical MW (kDa)
69.3
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-DMPK antibody (H00001760-B01) by Western Blots.
SDS-PAGE Gel
DMPK transfected lysate.
Western Blot
Lane 1: DMPK transfected lysate ( 69.3 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — DMPK
Entrez GeneID
1760GeneBank Accession#
NM_004409.2Protein Accession#
NP_004400.4Gene Name
DMPK
Gene Alias
DM, DM1, DM1PK, DMK, MDPK, MT-PK
Gene Description
dystrophia myotonica-protein kinase
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq
Other Designations
DM protein kinase|dystrophia myotonica 1|myotonic dystrophy associated protein kinase|myotonic dystrophy protein kinase|myotonin protein kinase A|thymopoietin homolog
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Interactome
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Disease
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