DHCR24 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-DHCR24 full-length
Host
Human
Theoretical MW (kDa)
56.87
Interspecies Antigen Sequence
Mouse (97); Rat (97)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-DHCR24 antibody (H00001718-B01) by Western Blots.
SDS-PAGE Gel
DHCR24 transfected lysate.
Western Blot
Lane 1: DHCR24 transfected lysate ( 56.87 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — DHCR24
Entrez GeneID
1718GeneBank Accession#
NM_014762.2Protein Accession#
NP_055577.1Gene Name
DHCR24
Gene Alias
KIAA0018, Nbla03646, SELADIN1, seladin-1
Gene Description
24-dehydrocholesterol reductase
Gene Ontology
HyperlinkGene Summary
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq
Other Designations
3 beta-hydroxysterol delta 24-reductase|OTTHUMP00000011685|diminuto/dwarf1 homolog|putative protein product of Nbla03646|selective AD indicator 1
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Interactome
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Pathway
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Disease
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