DHCR24 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human DHCR24 peptide using ARM Technology.
Immunogen
A synthetic peptide of human DHCR24 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human DHCR24 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — DHCR24
Entrez GeneID
1718GeneBank Accession#
DHCR24Gene Name
DHCR24
Gene Alias
KIAA0018, Nbla03646, SELADIN1, seladin-1
Gene Description
24-dehydrocholesterol reductase
Gene Ontology
HyperlinkGene Summary
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq
Other Designations
3 beta-hydroxysterol delta 24-reductase|OTTHUMP00000011685|diminuto/dwarf1 homolog|putative protein product of Nbla03646|selective AD indicator 1
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