Immunoprecipitation of DHCR24 transfected lysate using anti-DHCR24 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with DHCR24 purified MaxPab mouse polyclonal antibody (B01P) (H00001718-B01P).
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq
3 beta-hydroxysterol delta 24-reductase,OTTHUMP00000011685,diminuto/dwarf1 homolog,putative protein product of Nbla03646,selective AD indicator 1