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CDKN2B (Human) Recombinant Protein (P01)

  • Catalog # : H00001030-P01
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Human CDKN2B full-length ORF ( AAH14469, 1 a.a. - 138 a.a.) recombinant protein with GST-tag at N-terminal.
  • Sequence:
  • MREENKGIPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYLRTATGD
  • Host:
  • Wheat Germ (in vitro)
  • Theoretical MW (kDa):
  • 40.92
  • Purification:
  • Glutathione Sepharose 4 Fast Flow
  • Quality Control Testing:
  • 12.5% SDS-PAGE Stained with Coomassie Blue.

    QC Testing of H00001030-P01
  • Storage Buffer:
  • 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Best use within three months from the date of receipt of this protein.
  • Applications
  • Enzyme-linked Immunoabsorbent Assay
  • Western Blot (Recombinant protein)
  • Antibody Production
  • Protein Array
  • Application Image
  • Enzyme-linked Immunoabsorbent Assay
  • Western Blot (Recombinant protein)
  • Antibody Production
  • Protein Array
  • Gene Information
  • Entrez GeneID:
  • 1030
  • Gene Name:
  • CDKN2B
  • Gene Alias:
  • CDK4I,INK4B,MTS2,P15,TP15,p15INK4b
  • Gene Description:
  • cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
  • Gene Summary:
  • This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq
  • Other Designations:
  • CDK inhibitory protein,CDK4B inhibitor,OTTHUMP00000021154,OTTHUMP00000021155,cyclin-dependent kinase 4 inhibitor B,cyclin-dependent kinase inhibitor 2B,cyclin-dependent kinases 4 and 6 binding protein,multiple tumor suppressor 2,p14_CDK inhibitor,p14_INK4
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