CBS (Human) Recombinant Protein (P01)
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Human CBS full-length ORF ( AAH11381.1, 1 a.a. - 551 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPSRCTWQLGRPASESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDPEGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKAAQELQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEEDLTEKKPWWWHLRVQELGLSAPLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVGKVIYKQFKQIRLTDTLGRLSHILEMDHFALVVHEQIQYHSTGKSSQRQMVFGVVTAIDLLNFVAAQERDQK
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
86.35
Interspecies Antigen Sequence
Mouse (84); Rat (84)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
-
Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
-
Gene Info — CBS
Entrez GeneID
875GeneBank Accession#
BC011381Protein Accession#
AAH11381.1Gene Name
CBS
Gene Alias
HIP4
Gene Description
cystathionine-beta-synthase
Omim ID
236200Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. [provided by RefSeq
Other Designations
OTTHUMP00000109416|OTTHUMP00000109418|beta-thionase|cystathionine beta-synthase|methylcysteine synthase|serine sulfhydrase
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Hydrogen Sulfide Exerts Anti-oxidative and Anti-inflammatory Effects in Acute Lung Injury.
Zimmermann KK, Spassov SG, Strosing KM, Ihle PM, Engelstaedter H, Hoetzel A, Faller S.
Inflammation 2018 Feb; 41(1):249.
Application:WB-Ti, Mouse, Mouse lung.
-
Endogenously produced hydrogen sulfide is involved in porcine oocyte maturation in vitro.
Nevoral J, Zalmanova T, Zamostna K, Kott T, Kucerova-Chrpova V, Bodart JF, Gelaude A, Prochazka R, Orsak M, Sulc M, Klein P, Dvorakova M, Weingartova I, Vighova A, Hoskova K, Krejcova T, Jilek F, Petr J.
Nitric Oxide 2015 Dec; 51:24.
Application:IF, WB, Porcine, Oocytes.
-
HYDROGEN SULFIDE (H2S) AUGMENTS SYNAPTIC NEUROTRANSMISSION IN THE NUCLEUS OF THE SOLITARY TRACT (NTS).
Austgen JR, Hermann GE, Dantzler HA, Rogers RC, Kline DD.
Journal of Neurophysiology 2011 Oct; 106(4):1822.
Application:IF, Rat, Brain.
-
The Effect of Hydrogen Sulfide Donors on Lipopolysaccharide-Induced Formation of Inflammatory Mediators in Macrophages.
Whiteman M, Li L, Rose P, Tan CH, Parkinson DB, Moore PK.
Antioxidants & Redox Signaling 2010 May; 12(10):1147.
Application:Func, Buffer.
-
Hydrogen Sulfide Exerts Anti-oxidative and Anti-inflammatory Effects in Acute Lung Injury.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com