CAV1 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-CAV1 full-length
Host
Human
Theoretical MW (kDa)
20.5
Interspecies Antigen Sequence
Mouse (95); Rat (95)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-CAV1 antibody (H00000857-D01P) by Western Blots.
SDS-PAGE Gel
CAV1 transfected lysate.
Western Blot
Lane 1: CAV1 transfected lysate ( 20.50 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — CAV1
Entrez GeneID
857GeneBank Accession#
NM_001753.3Protein Accession#
AAH82246.1Gene Name
CAV1
Gene Alias
BSCL3, CAV, CGL3, MSTP085, VIP21
Gene Description
caveolin 1, caveolae protein, 22kDa
Omim ID
601047Gene Ontology
HyperlinkGene Summary
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. [provided by RefSeq
Other Designations
OTTHUMP00000025031|caveolae protein, 22-kD|caveolin 1|caveolin 1 caveolae protein, 22kD|caveolin 1, alpha isoform|caveolin 1, beta isoform|caveolin-1 beta isoform protein|cell growth-inhibiting protein 32
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Interactome
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Pathway
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Disease
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