Western blot analysis of BMPR1B over-expressed 293 cell line, cotransfected with BMPR1B Validated Chimera RNAi ( Cat # H00000658-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with BMPR1B monoclonal antibody (M01) clone 2F3 (Cat # H00000658-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. [provided by RefSeq