Products

Western Blot (Transfected lysate)

Western Blot analysis of ACTN1 expression in transfected 293T cell line (H00000087-T01) by ACTN1 MaxPab polyclonal antibody.

Lane 1: ACTN1 transfected lysate(103.10 KDa).
Lane 2: Non-transfected lysate.

In situ Proximity Ligation Assay (Cell)

Proximity Ligation Analysis of protein-protein interactions between ACTN1 and CAMK2A. HeLa cells were stained with anti-ACTN1 rabbit purified polyclonal 1:1200 and anti-CAMK2A mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).

Entrez GeneID

87

GeneBank Accession#

NM_001102.2

Protein Accession#

NP_001093.1

Gene Name

ACTN1

Gene Alias

FLJ40884

Gene Description

actinin, alpha 1

Omim ID

102575

Gene Ontology

Hyperlink

Gene Summary

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

F-actin cross-linking protein|actinin 1 smooth muscle|alpha-actinin 1