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BIOtech
BULK-new

Anti-ACTN4 monoclonal antibody

  • Catalog # : DH0003
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Anti-ACTN4 is a useful marker in molecular phenotyping of tumors such as non-small cell lung cancer, pancreatic and ovarian cancers.
  • Immunogen:
  • A synthetic peptide NQSYQYGPSSAGNGA
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • Human Actinin, Alpha 4
  • Isotype:
  • IgG2b
  • Storage Buffer:
  • In 1x PBS, pH 7.2
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Regulation Status:
  • For in vitro diagnostic use (USA and Taiwan)
  • Clone Name:
  • Monoclonal antibody (13G9)
  • Publication Reference
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) enlargeenlarge this image
  • Immunoperoxidase of monoclonal antibody to ACTN4 on formalin-fixed paraffin-embedded human lung adenocarcinoma. [antibody concentration 1.5 ug/ml]
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) enlargeenlarge this image
  • Immunoperoxidase of monoclonal antibody to ACTN4 on formalin-fixed paraffin-embedded human ovarian cancer. [antibody concentration 1.5 ug/ml]
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) enlargeenlarge this image
  • Immunoperoxidase of monoclonal antibody to ACTN4 on formalin-fixed paraffin-embedded human pancreatic cancer. [antibody concentration 1.5 ug/ml]
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 81
  • Gene Name:
  • ACTN4
  • Gene Alias:
  • ACTININ-4,DKFZp686K23158,FSGS,FSGS1
  • Gene Description:
  • actinin, alpha 4
  • Gene Summary:
  • Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq
  • Other Designations:
  • actinin alpha4 isoform
  • Interactome
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