Integrated, High Throughput Antibody Production
Rabbit monoclonal antibody (Mab) is secreted by the plasma B-cell of the rabbit. Traditional generation of rabbit Mab relies on a rabbit myeloma for B-cell fusion (<1% fusion rate) and hybridoma development. Rabbit Monoclonal Antibody (Phage Antibody Library, PAL) uses a non-fusion Fab antibody library to produce rabbit Mab in vitro. PAL platform utilizes the entire rabbit antibody repertoire to screen for high affinity and high specificity Fab binders with broad epitope coverage to antigen of interest. PAL has higher antibody screening throughput and success rate. PAL Fab is amenable to antibody engineering including F(ab)2, IgG, scFv and multitude of different Fc and non-Fc conjugates. PAL technology is the solution to high quality reagents for research and commercial developments.