ACE2 (Human) Recombinant Protein (Biotin)
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More Files
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Enzyme-linked Immunoabsorbent Assay
Immobilized SARS-COV-2 Spike RBD, His Tag at 2 ug/mL (100 uL/well) on the plate. Dose response curve for Biotinylated Human ACE2, His Tag with the EC50 of 0.11 ug/mL determined by ELISA.
Tris-Bis PAGE
Biotinylated Human ACE2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
SEC-HPLC
The purity of Biotinylated human ACE2 is greater than 95% as determined by SEC-HPLC.
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Specifications
Product Description
Human ACE2 (Q9BYF1-1, Gln18-Ser740) partial recombinant protein with His-Avi tag at the C-Terminus expressed in HEK293 cells.
Sequence
Gln18-Ser740
Host
Human
Theoretical MW (kDa)
86.5
Reactivity
Human
Form
Lyophilized
Conjugation
Biotin
Preparation Method
Mammalian cell (HEK293) expression system
Purity
> 95% by Tris-Bis PAGE
> 95% by HPLCEndotoxin Level
< 0.1 EU per 1 ug as determined by the LAL method.
Activity
The EC50 was 0.11 ug/mL, measured by ELISA at 2 ug/mL.
Recommend Usage
Biological Activity
ELISA
Tris-Bis PAGE
SEC-HPLC
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.22 um filtered solution in PBS, pH 7.4. (8% trehalose).
Storage Instruction
Store at -20°C for 12 months.
After reconstitution, store at 4°C for 2-7 days, or store at -80°C for 3-6 months.
Aliquot to avoid repeated freezing and thawing.Note
Please use within one month after protein reconstitution.
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Applications
Enzyme-linked Immunoabsorbent Assay
Immobilized SARS-COV-2 Spike RBD, His Tag at 2 ug/mL (100 uL/well) on the plate. Dose response curve for Biotinylated Human ACE2, His Tag with the EC50 of 0.11 ug/mL determined by ELISA.Functional Study
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Gene Info — ACE2
Entrez GeneID
59272Protein Accession#
Q9BYF1-1Gene Name
ACE2
Gene Alias
ACEH, DKFZp434A014
Gene Description
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
Omim ID
300335Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq
Other Designations
ACE-related carboxypeptidase|OTTHUMP00000022963|angiotensin I converting enzyme 2|angiotensin converting enzyme-like protein
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Interactomes
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Pathways
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Diseases
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