KLRC2/KLRD1 (Human) Recombinant Protein
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More Files
- More Functions
Surface Plasmon Resonance
Human NKG2C&CD94, His Tag immobilized on CM5 Chip can bind Human HLA-E*01:03 Complex Tetramer, His Tag with an affinity constant of 1.65 uM as determined in SPR assay (Biacore T200).
SEC-HPLC
The purity of Human NKG2C&CD94 is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human NKG2C&CD94 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.
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Specifications
Product Description
Human KLRC2/KLRD1 (P26717/Q13241-1, Glu98-Leu231/Ser34-Ile179) partial recombinant protein with His-Avi tag at N-terminus expressed in HEK293 cells.
Sequence
Glu98-Leu231;Ser34-Ile179
Host
Human
Theoretical MW (kDa)
15.3
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purity
> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Level
< 1 EU per 1 ug of protein (determined by LAL method)
Quality Control Testing
SEC-HPLC
SEC-HPLC
The purity of Human NKG2C&CD94 is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human NKG2C&CD94 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.
Recommend Usage
Biological Activity
ELISA
SEC-HPLC
SPR
Tris-Bis PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from filtered solution in PBS, pH 7.4 (5% trehalose).
Storage Instruction
After reconstitution with deionized water to a final concentration more than 100 ug/ml, store at 4°C for 1 week. For long term storage, store at -80°C for 1 year.
Aliquot to avoid repeated freezing and thawing. -
Applications
Enzyme-linked Immunoabsorbent Assay
Functional Study
Surface Plasmon Resonance
Human NKG2C&CD94, His Tag immobilized on CM5 Chip can bind Human HLA-E*01:03 Complex Tetramer, His Tag with an affinity constant of 1.65 uM as determined in SPR assay (Biacore T200). -
Gene Info — KLRC2
Entrez GeneID
3822Protein Accession#
P26717;Q13241-1Gene Name
KLRC2
Gene Alias
CD159c, MGC138244, NKG2-C, NKG2C
Gene Description
killer cell lectin-like receptor subfamily C, member 2
Omim ID
602891Gene Ontology
HyperlinkGene Summary
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq
Other Designations
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Gene Info — KLRD1
Entrez GeneID
3824Protein Accession#
P26717;Q13241-1Gene Name
KLRD1
Gene Alias
CD94
Gene Description
killer cell lectin-like receptor subfamily D, member 1
Omim ID
602894Gene Ontology
HyperlinkGene Summary
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq
Other Designations
CD94 antigen
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Interactomes
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Pathways
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Diseases
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