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Flow Cytometry

Western Blot

Immunofluorescence

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

ARRB2

Gene Alias

ARB2, ARR2, BARR2, DKFZp686L0365

Gene Description

arrestin, beta 2

Omim ID

Gene Ontology

Gene Summary

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq

Other Designations

arrestin 3