Products

Western Blot

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

ACTN1

Gene Alias

FLJ40884

Gene Description

actinin, alpha 1

Omim ID

Gene Ontology

Gene Summary

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

F-actin cross-linking protein|actinin 1 smooth muscle|alpha-actinin 1