AADAC monoclonal antibody (M01), clone 2E8
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More Files
- More Functions
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged AADAC is approximately 3ng/ml as a capture antibody.
Western Blot detection against Immunogen (36.74 KDa) .
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Specifications
Product Description
Mouse monoclonal antibody raised against a partial recombinant AADAC.
Immunogen
AADAC (NP_001077, 201 a.a. ~ 300 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
QLLDDPDVKIKLKIQSLIYPALQPLDVDLPSYQENSNFLFLSKSLMVRFWSEYFTTDRSLEKAMLSRQHVPVESSHLFKFINWSSLLPERFIKGHVYNNP
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (73); Rat (69)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged AADAC is approximately 3ng/ml as a capture antibody.ELISA
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Gene Info — AADAC
Entrez GeneID
13GeneBank Accession#
NM_001086Protein Accession#
NP_001077Gene Name
AADAC
Gene Alias
CES5A1, DAC
Gene Description
arylacetamide deacetylase (esterase)
Omim ID
600338Gene Ontology
HyperlinkGene Summary
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq
Other Designations
arylacetamide deacetylase
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Interactomes
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Pathways
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Diseases
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Publication Reference
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N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity.
Muta K, Fukami T, Nakajima M, Yokoi T.
Biochemical Pharmacology 2014 Jan; 87(2):352.
Application：WB-Ce, WB-Tr, Human, Huh7 cells, Liver microsomes.
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Metabolic activation by human arylacetamide deacetylase, CYP2E1, and CYP1A2 causes phenacetin-induced methemoglobinemia.
Kobayashi Y, Fukami T, Higuchi R, Nakajima M, Yokoi T.
Biochemical Pharmacology 2012 Nov; 84(9):1196.
Application：WB-Ti, Mouse, Liver.
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A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity.
Shimizu M, Fukami T, Kobayashi Y, Takamiya M, Aoki Y, Nakajima M, Yokoi T.
Drug Metabolism and Disposition 2012 Jun; 40(6):1183.
Application：WB-Ce, Monkey, COS7 cells.
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Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse.
Kobayashi Y, Fukami T, Nakajima A, Watanabe A, Nakajima M, Yokoi T.
Drug Metabolism and Disposition 2011 Dec; 40(4):671.
Application：WB, Human, Mouse, Rat, Sf21 cells (insect cells).
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Human Arylacetamide Deacetylase Is A Principal Enzyme in Flutamide Hydrolysis.
Watanabe A, Fukami T, Nakajima M, Takamiya M, Aoki Y, Yokoi T.
Drug Metabolism and Disposition 2009 Jul; 37(7):1513.
Application：WB-Tr, Monkey, COS-7 cells.
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N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity.
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