Products

Western Blot (Cell lysate)

MAPKAPK3 monoclonal antibody (M06), clone 4B11 Western Blot analysis of MAPKAPK3 expression in HL-60 ( Cat # L014V1 ).

Western Blot (Recombinant protein)

ELISA

Entrez GeneID

7867

GeneBank Accession#

NM_004635

Protein Accession#

NP_004626

Gene Name

MAPKAPK3

Gene Alias

3PK, MAPKAP3

Gene Description

mitogen-activated protein kinase-activated protein kinase 3

Omim ID

602130

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. [provided by RefSeq

Other Designations

MAPKAP kinase 3