Products

Antibody Production

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

ENPP1

Gene Alias

M6S1, NPP1, NPPS, PC-1, PCA1, PDNP1

Gene Description

ectonucleotide pyrophosphatase/phosphodiesterase 1

Omim ID

Gene Ontology

Gene Summary

This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance. [provided by RefSeq

Other Designations

Ly-41 antigen|OTTHUMP00000043194|alkaline phosphodiesterase 1|membrane component, chromosome 6, surface marker 1|phosphodiesterase I/nucleotide pyrophosphatase 1|plasma-cell membrane glycoprotein 1