Products

Western Blot (Recombinant protein)

Sandwich ELISA (Recombinant protein)

Detection limit for recombinant GST tagged DSCR1 is approximately 0.3ng/ml as a capture antibody.

ELISA

Immunofluorescence

Immunofluorescence of monoclonal antibody to RCAN1 on HeLa cell . [antibody concentration 10 ug/ml]

Entrez GeneID

1827

GeneBank Accession#

BC002864

Protein Accession#

AAH02864

Gene Name

RCAN1

Gene Alias

ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1

Gene Description

regulator of calcineurin 1

Omim ID

602917

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq

Other Designations

Down syndrome candidate region 1|Down syndrome critical region gene 1|calcipressin 1|calcium and oxidant-inducible mRNA|modulatory calcineurin-interacting protein 1|myocyte-enriched calcineurin-interacting protein 1|near DSCR proline-rich protein